Eastwood is a keen-eyed quick witted bounty hunter on the bloody trail of Indio, the territory's most treacherous bandit. But his ruthless rival, Colonel Mortimer (Lee Van Cleef), is determined to bring Indio in first: dead or alive! Failing to capture their prey, or eliminate each other, the two are left with only one option: team up, or face certain death at the hands of Indio and his band of murderous outlaws...