In this sequel to director John Badham's STAKEOUT, Seattle detectives Chris Lecce (Richard Dreyfuss) and Bill Reimers (Emilio Estevez) are assigned another stakeout operation. When Lu Delano (Cathy Moriarty), an important witness against the mafia mysteriously disappears, the district attorney's office comes up with an elaborate scheme to recover her. Thought to be hiding out with the O'Haras, a local family on a Pacific Northwest island, Lecce and Reimers are assigned to watch over the household. However, they are joined on their stakeout by a new supervisor, federal prosecutor Gina Garret (Rosie O'Donnell) and her "loveable" rottweiler Archie. Posing as an all-American family, Lecce, Reimers, and Garrett move in next door to the O'Haras in a hysterical battle of the wills. Mayhem ensues as the trio attempt to keep their operation a secret and stay one-step ahead of the mafia.