When a writing assignment lands journalist Raoul Duke (Johnny Depp) and sidekick Dr. Gonzo (Benicio Del Toro) in Las Vegas, they decide to make it the ultimate business trip. But before long, business is forgotten and trip has become the key word. Fuelled by a suitcase full of mind-bending pharmaceuticals, Duke and Gonzo set off on a fast and furious ride through non-stop neon, surreal surroundings and a craw of the craziest characters ever (appearances by Cameron Diaz, Christina Ricci, Gary Busey and many others). But no matter where misadventure leads them, Duke and Gonzo discover that sometimes going too far is the only way to go...