Ghost Of Mae Nak is a re-telling of a Thai spirit tale that had seen no fewer than 20 previous cinematic renderings. All can be traced to a famous old legend in which a young pregnant woman named Nak and her baby die during childbirth, and later come back to haunt her husband Mak.

Mak and Nak, a young newlywed couple in Bangkok, acquire an antique brooch and an old abandoned house that soon bring them into contact with Mae Nak Phrakhanong, a figure of horror and despair from one of Thailand's most enduring ghost legends.

While Mae Nak's ghost protects the couple from an unscrupulous real estate agent as well as a pair of burglars, it becomes apparent that she expects a terrible favour in return.

Mak, the young groom, is incapacitated by a powerful coma, and his bride Nak must exhume Mae Nak's corpse from its hidden grave so that the skull can be restored using the antique brooch. Only in this way can Mae Nak's spirit finally be set free.