As Mini's First Time begins, teenaged Mini's (Nikki Reed) life with neglectful mom Diane (Carrie-Anne Moss) has reached breaking point. Fed up with Diane's insatiable appetite for sex and alcohol, Mini decides to grab life by the lapels, and ventures out to try as many new experiences as she can. Her first challenge presents itself when she decides to become a call girl. Vamping it up, the young girl takes on the role of an embittered seductress, but runs into trouble when her second client is none other than her stepfather, Martin (Alec Baldwin). The film then takes a surprising twist, with Mini and Martin indulging in a passionate affair and plotting to get rid of Diane, for whom they both have a deep-seated hatred.

Writer/Director Nick Guthe laces his story with dark humor, pulling impressive performances out of Reed and Baldwin.