Computer programmer Paul Hackett (Griffin Dunne) makes a casual date with Marcy (Rosanna Arquette), a woman he meets in a coffee shop, unaware that it's about to unleash a nightmarish odyssey through the bowels of lower Manhattan. Upon arriving at Marcy's spacious Soho loft, Paul meets her unnerving artist roommate, Kiki (Linda Fiorentino), and the night takes a turn for the worse. Sensing the bad vibes that lie ahead, he immediately decides to return to his home on the Upper East Side. Unfortunately, this isn't such an easy task. In a seemingly endless series of strange and dangerous encounters, Paul begins to fear that he might never make it home again.