On the surface, Jerry Stahl (Ben Stiller) seems to have it all. A successful career as a top Hollywood television scriptwriter earning $5,000 a week, married to beautiful British television executive, Sandra (Elizabeth Hurley), and a baby on the way. But behind the glossy facade lies a desperate junkie whose life is fast spiralling out of control.

Having checked into a rehab clinic in the Arizona desert, Jerry starts a torrid affair with Kitty (Maria Bello), a hardened but attractive recovering addict like himself, and together they face the challenging journey towards recovery in search of a brighter future. Based on Jerry Stahl's gripping autobiography, Permanent Midnight paints an alarming, but fascinating portrait of drugs in Tinseltown in this powerful story of one man's struggle against addiction.