A crime thriller with separate yet interconnected stories involving characters including: a psychology professor who has lost touch with reality (MacFadyen); a young sociopathic call girl (Chabert); a vicious lesbian hit woman (Bennett); a recovering crack addict and kidnapper (Holly); a junkyard drunk (Meat Loaf); a brain-damaged former cult guru (Spizzirri); and dueling gas station attendants (Dratch and Mewes).