Eddie Murphy stars as Dr Sherman Klump, a kind "calorically challenged" genetics professor who longs to shed his 400-pound frame in order to win the heart of beautiful Jada Pinkett. So with one swig of his experimental fat-reducing serum, Sherman becomes "Buddy Love", a fast-talking, pumped-up, plumped-down Don Juan. Can Sherman stop his buff alter ego before it's too late, or will Buddy have the last laugh?