Michael and Bruno though half-brothers, are completely different. They share only a mother in common who neglected them to lead a carefree jet-set life leaving them in the care of separate grandparents. Introverted molecular biologist Michael is so wrapped up in his genetic research that he shies away from intimacy while Bruno is a slave to his fantasies paying for sexual favors. Everything changes when both men, now thirty-something, find love. Michael happens to re-unite with his childhood sweetheart, Annabelle and Bruno meets Christiane who shares and enjoys his sexual obsessions. Although it seems that luck is finally on their side, by a cruel twist of fate, both women suddenly become seriously ill. Stunned, Bruno and Michael must deal with the aftermath and decide whether to stay in difficult relationships or return to their lonely lives.