Uncle P is the story of a multimillion-dollar businessman in New York known as P Miller (short for his real name, Percy Miller), who is also a world-famous rapper. When Miller's sister, a single mother living in suburban California, becomes ill, she asks her brother to come and take care of her three children. Upon arrival, Miller finds himself out of his element as he becomes the children's caretaker and surrogate father. The more time he spends with them, the more he realizes there is more to life than his business, and he slowly begins to learn the importance of family. He also helps the kids with their own problems.