Damien Thorn (Sam Neill) has helped rescue the world from a recession, appearing to be a benign corporate benefactor. When he then becomes U.S Ambassador to England, Damien fulfills a terrifying biblical prophecy. He also faces his own potential demise as an astronomical event brings about the second coming of Christ.

Determined to thwart his holy arch-nemesis, as well as a group of priests intent on killing him, Damien begins his most destructive rampage yet...