Most men would do anything to get out of Fox River Penitentiary, but Michael Scofield (Wentworth Miller) will do anything to get in. His brother Lincoln (Dominic Purcell) has been sentenced to die for a crime he did not commit, and the only way to save him is from the inside out.

Armed with secret prison blueprints and an impossibly intricate escape plan, Michael gets himself incarcerated, and the race against time in on. Now, he'll need all of the cunning, daring, and luck he can muster...along with the assistance of some of the prison's most vile and dangerous felons.