In another of his classic Westerns, John Ford again reflects upon the advance of civilisation on the receding frontier, recounting the events leading up to and including the legendary gunfight at the O.K. Corral.

Wyatt Earp and his brothers Morgan and Virgil ride into Tombstone and leave brother James in charge of their cattle herd. On their return they find their cattle stolen and James dead. Wyatt takes on the job of town marshal, making his brothers deputies, and vows to stay in Tombstone until James' killers are found. He soon runs into the brooding, coughing, hard-drinking Doc Holliday as well as the sullen and vicious Clanton clan. Wyatt discovers the owner of a trinket stolen from James' dead body and the stage is set for the Earps' long-awaited revenge.