Cybill Sheridan (Cybill Shepherd) is a working actress in her forties, living in natural disaster-prone Los Angeles, striving to find meaningful roles and maintain a living in an industry that worships youth. Keeping everything in perspective are her two daughters (Dedee Pfeiffer and Alicia Witt), two ex-husbands (Alan Rosenberg and Tom Wopat) and a best friend (Christine Baranski) who is the best at turning life's little predicaments into hysterical and humbling one-liners!