Best friends since they were kids, Jacob Schram (Ben Stiller) and Brian Finn (Edward Norton) are dynamic and popular young men living and working on New York's Upper West Side. When Anna Reilly (Jenna Elfman), once their childhood friend and now grown into a beautiful corporate executive, suddenly returns to the city, she re-enters Jake and Brian's lives, and hearts, with a vengeance. Sparks fly and an unusual and complicated love triangle ensues, not least that Jacob is a Rabbi and Brian's a Priest but faith could steal both men's hearts...