In this latest chapter Rambo has withdrawn away from his dangerous life to a simple and secluded existance in Thailand where he spends his time chauffering locals up the river in his old PT boat. Despite trying his best to avoid trouble he is recruited by missionaries who are travelling up river to help the oppressed local people against the brutal rule of the murderous Burmese military. After witnessing a sadistic raid by Major Pa Tee Tint in which many locals are tortured and murdered the missionaries plead with Rambo to help their cause of liberating the survivors. Unable to stay behind he joins with them in what may be his deadliest mission ever.